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Diet is the foundation, but during an acute outbreak, many experts recommend 1,000mg to 3,000mg of L-Lysine daily (in divided doses) combined with a strict high-lysine diet to shorten healing time

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Such high micromolar GSSG concentrations are unlikely to occur in most subcellular compartments but could be reached in the secretory pathway or during titration experiments of transgenic cell lines with an upregulated GSSG transporter 35,63,64,77