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This reduces the susceptibility of the immortalized cells to drug toxicity and even switches the mode of cell death from necrosis in primary hepatocytes to caspase-dependent apoptosis in hepatoma cells [140, 141]

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[DOI] [PMC free article] [PubMed] 38.Silva ABD, Medeiros JFP, Lima MSR, Mata A, Andrade EDO, Bezerra DS, Osorio MM, Dimenstein R, Ribeiro K