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For example, small EVs derived from mesenchymal stem cells have been shown to diminish senescent biomarkers and restore angiogenesis and other dysfunctions in senescent EC stimulated by oxidative stress in vitro

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To define the consequences of constitutive nuclear localization and activation of FOXO1, the Accili group developed a series of FOXO1 mutants, which are unable to be posttranslationally modified at key serine, threonine, and lysine residues, preventing its exclusion from the nucleus in response to AKT activation (231, 262)

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