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The basal PKC activity required for this mechanism also has several potential sources in neurons, signalling through either brain-derived neurotrophic factor 56,57 , metabotropic glutamate receptors 58,59 or other forms of neuromodulation 60,61 , all of which could potentially increase PKC activity leading to the phosphorylation of GABA A Rs and alterations in the efficacy of inhibitory synapses
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