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Exploratory celiotomy and full-thickness biopsy may be necessary, although this is more invasive and wound healing can be problematic if severe hypoproteinemia is present

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While glucagon traditionally raises blood glucose, the concurrent GLP-1 and GIP agonism counterbalances this hyperglycemic effect, allowing retatrutide to achieve net glycemic improvement while harnessing glucagon's catabolic benefits for energy expenditure and liver fat clearance