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Collectively, the data thus indicated the molecular events of gene expression for tenocyte (COL1A1 and TNC) and cellular events of proliferation and differentiation could be crucial to maintain the tendon-lineage phenotype for tendon regeneration

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In OA and other chronic degenerative disorders, cells and tissues also undergo shifts in energy metabolism and biosynthetic pathways to adapt to pathological microenvironments characterized by hypoxia, inflammation, mechanical stress, and nutrient limitation ( 3.1 Lipid metabolic reprogramming 3.1.1 PUFAs and lipid peroxidation Lipid peroxidation is the central event in ferroptosis