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As a way to find out if transcription factors (TFs) known to be key regulators of carbohydrate and lipid metabolism, oxidative stress and longevity, such as HIF-1/HIF1α, CRH-1/CREB, CEP-1/p53, SKN-1/NRF2, SBP-1/SREBP, and DAF-16/FOXO, were involved in the glucose-dependent reduction in lifespan observed in the wild-type strain, we assessed the longevity of mutants or RNAi knock-downs of the previously mentioned TFs in worms grown at 100 mM glucose (Fig 7B–7H and S2 Table)
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