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Finally, lactic acid causes a reduction in LDH-A expression, which is paralleled by diminished tumor growth and a decline in the number of MDSCs ( Within such a scenario, metabolic reprogramming has multiple effects, including the extracellular accumulation of nucleotides (ATP, NAD + , cAMP) and of ADO, its main catabolic product ( The partial block of ADORA2A may increase the concentration of extracellular AMP, favoring internalization and accumulation of the mononucleotide inside the cell

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But here’s the truth: ⚠️ Not all NAD+ therapies are created equal