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This includes nicotinamide riboside kinases, nicotinamide phosphoribosyltransferase, and other methyltransferases that could confound experimental results

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Semaglutide was initiated at 0.25 mg per week for the first 4 weeks via a pre-filled pen injector, escalating in a fixed-dose regimen every 4 weeks to reach the maintenance dose of 2.4 mg by week 16 (lower maintenance doses were permitted if participants were unable to tolerate 2.4 mg) (Extended Data Fig