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Krüppel‐like factors family in health and disease - Xiang - 2024 - MedComm - Wiley Online Library

This gradual reduction is closely associated with the hallmarks of aging: increased body fat, loss of muscle mass, slower recovery, reduced energy, diminished libido, and declining mental acuity

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These hurdles include the inherent complexity and significant inter-individual variability of the axis, challenges in achieving precise and safe interventions, and methodological barriers in clinical trial design and biomarker development, all of which impede rapid ‘bench to bedside’ translation (163, 164)