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Environmental toxins such as heavy metals and polycyclic aromatic hydrocarbons can disrupt histone acetyltransferase (HAT) and histone deacetylase (HDAC) activity, causing changes in chromatin compaction that either repress or activate oncogenic gene expression [43,44,45]

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Additionally, DCs upregulate IL-10 gene transcription while downregulating IFN-γ gene transcription