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Two sets of studies were performed that looked at BSO effects after 5 or 15 days of CS exposure

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In AhR-expressing intratumoural CD8 + T cells, active kynurenine transport activates AhR-dependent transcription of PDCD1 , whereas IL-2–STAT5-driven TPH1 expression promotes tryptophan catabolism to 5-hydroxytryptophan (5-HTP), further enabling AhR-mediated induction of exhaustion-associated genes such as PDCD1 , LAG3 , ENTPD1 (CD39) and HAVCR2 128,129