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NSC-34 cells overexpressing TDP-43 M337V showed increased values of intracellular lipid peroxidation, lower cell viability, nuclear accumulation of Nrf2, and decreased protein expression of NAD(P)H quinone dehydrogenase 1 (NQO1, downstream Nrf2 antioxidant), suggesting that TDP-43 M337V weakened cellular antioxidant defenses, which turned the cells more susceptible to the increase of OS [115]