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Although this latter study using Dm GPx was based on high-definition crystallographic data for GPx-4, molecular modeling suggests that the Asn may also be essential in GPx-1 (359) and that the functional catalytic site is actually a tetrad

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In obesity, HDL functionality is often compromised, impairing reverse cholesterol transport and exacerbating lipid accumulation and atherosclerotic risk (Lecerf & De Lorgeril, 2011)