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Common Symptoms of Rotator Cuff Tendinitis: Persistent, dull ache in the shoulder Pain that may radiate down the arm, affecting the upper arm or even the neck Weakness in the affected shoulder, making it challenging to lift or carry objects Limited range of motion in the shoulder joint, with difficulty reaching overhead Pain exacerbated by specific arm movements, such as reaching or lifting Discomfort that intensifies at night, particularly when lying on the affected side Shoulder Arthritis Shoulder arthritis is a degenerative joint condition that affects the shoulder’s smooth cartilage lining

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This highlights the need for strategies to overcome the restrictive nature of the BBB and the lack of drug targeting specificity which hinder delivery of adequate drug concentrations in the affected brain regions