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137 , 138 , 139 , 140 Sulfate-reducing bacteria, such as Desulfovibrio desulfuricans , Desulfovibrio vulgaris , and Desulfovibrio indonesiensis , are key producers of hydrogen sulfide (H 2 S), which has been associated with gut barrier dysfunction, systemic inflammation, and increased BBB permeability, thereby contributing to the pathogenesis of both AD and PD