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Funding Statement This work was supported by grants from the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health (R01AR073172 and 1R21AR083066 to W.T.) and Department of Defense (HT9425-23-10008 to W.T.), and National Heart, Lung, and Blood Institute (R01HL160541 to T.C.) and National Center for Advancing Translational Science (R03TR004450 to T.C.)
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In addition, DHA induced ferroptosis as an antitumor agent in primary liver cancer (PLC) by activating the anti-survival unfolded protein response (UPR) and upregulating Chac GSH –specific γ-glutamylcyclo-transferase 1 (CHAC1) expression, which was significantly attenuated by Fer-1 and DFO application after iron loading (95)