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New approaches to develop drugs for the treatment of AD that prevent free radical production and hence neurodegeneration including AGE-inhibitors, antioxidants and anti-inflammatory substances are being emphasized

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Discussion Through comparative analysis of mouse transcriptome and worm proteome-transcriptome following doxycycline treatment and mrps-5 RNAi, respectively, we identified a panel of candidates potentially responsible for the beneficial effects observed upon mitochondrial translation inhibition