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When NF-kB translocates to the cell nucleus, it switches on the transcription of pro-inflammatory cytokines including TNF-alpha, IL-6, and IL-1-beta

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Neutrophils infiltrate diabetic kidneys via ICAM-1/MCP-1-mediated chemotaxis, releasing neutrophil extracellular traps (NETs) enriched in histones and proteases that induce podocyte detachment and tubular injury (83, 84)