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Instead of blocking monoamine reuptake, esketamine works as a non-selective, non-competitive antagonist of N-methyl-D-aspartate (NMDA) receptors, an ionotropic glutamate receptor, preferentially targeting those located on GABA interneurons

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For a 52-year-old executive experiencing cognitive decline that's affecting job performance, spending $1,000-$2,400 on an initial NAD+ protocol to see if it restores clarity might be a rational investment