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Mammalian TrxRs are homodimeric selenoenzymes of 55-60 kDa in a head-to-tail conformation, with every subunit containing a flavin adenine dinucleotide, an NADPH-binding domain, and the C-terminal active site motif GCUC

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In Arabidopsis , KAKTUS ( KAK ) encodes a HECT-type E3 ubiquitin ligase that negatively regulates endoreduplication cycles in trichome branching by accelerating GL3 and EGL3 degradation (El Refy et al., 2004)

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