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The human genome encompasses over 30 genes encoding RGS or RGS-like domains, organized into at least six distinct subfamilies based on amino acid sequence similarity (Hollinger and Hepler, 2002
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Additionally, GRK2 mediates the phosphorylation-independent desensitization of several GPCRs, including thromboxane A2 receptor (TXA2R), M1 and M3 muscarinic receptors, parathyroid hormone (PTH) receptors, thyrotropin-releasing hormone (TRH) receptors, and angiotensin Ⅱ (Ang Ⅱ) receptors, as well as mGluR1 and β3-adrenergic receptor (β3-AR) [34]
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