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In repeated-dose Good Laboratory Practice (GLP) safety assessments conducted in cynomolgus monkeys, BYON3521 was well tolerated, with the highest non-severely toxic dose established at 15 mg/kg, based on safety data from cynomolgus monkeys, a human PK model estimated the minimal efficacious dose in humans to be between 3 to 4 mg/kg (110)
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These microorganisms have been shown to improve fish health, growth performance, and survival rates, as well as enhance the expression of several immunological factors and reduce the pathogen load to the gut mucus layer ( Oreochromis niloticus ) fed with the probiotic strain of Lactobacillus sp (Hamdan et al., 2016)
