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Signals from the gut influence appetite, satiety, and energy balance through: The vagus nerve Hormonal signaling Microbial metabolites Key metabolic hormones produced or influenced by the gut include: GLP-1 (glucagon-like peptide-1) – enhances insulin secretion and promotes satiety Peptide YY (PYY) – signals fullness Ghrelin – stimulates hunger When gut health is disrupted, these signals can become dysregulated, potentially contributing to overeating or impaired metabolic control

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The search for the molecular components of calcium entry has identified the stromal interaction molecule 1 (STIM1), as the calcium sensor of the intracellular calcium stores, and Orai as well as TRP channels as the calcium-permeable channels located in the plasma membrane