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Gastrointestinal conditions significantly impair B12 absorption: Pernicious anaemia , an autoimmune condition affecting intrinsic factor production, requires lifelong intramuscular B12 injections (hydroxocobalamin 1 mg every 2–3 months for maintenance, or every 2 months if neurological involvement) as oral absorption is severely compromised

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In preclinical CNS models, multiple strategies targeting the NLRP3 inflammasome axis have shown promise