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The first patient, treated in 1906, was a 50 year old dying man who had just had his toe amputated due to gangrene from diabetes and was in a diabetic coma
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These data present a plausible mechanism for a direct inhibitory effect of SARS-CoV-2 replication on the expression of a specific set of selenoprotein mRNA which may be relevant to the correlations between dietary Se status and the outcome of SARS-CoV-2 infection (Reference Wang, Huang and Sun66)