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Additionally, gut microbiota influence neurotransmitters via metabolites and vagal pathways

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For instance, a co-delivery system combining dexamethasone microcrystals and lidocaine-loaded poly (lactic-co-glycolic acid) (PLGA) non-spherical microparticles demonstrated prolonged drug retention in the perilymph and improved pharmacokinetics in guinea pig models, offering a promising approach for conditions like sudden SNHL associated with tinnitus (Wang et al., 2025)