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226 Aberrant sialylation can promote CD4 + T-cell activation, leading to the occurrence of UC, while deficiency of the α-2,6-sialyltransferase ST6GAL1 inhibits the process of sialylation and limits CD4 + T cell activation by suppressing the expression of NF-κB, subsequently decreasing the production of proinflammatory cytokines and alleviating UC

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