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The potential oxidative stress resulting from extracellular Hb is further exacerbated by a dramatic increase in rates of autoxidation for partially oxygenated Hb formed in the microcirculation, as well as an increase in the rate of autoxidation of Hb dimers formed when the Hb tetramer dissociates into dimers (Figure 1) at the reduced Hb concentration in plasma (Zhang et al., 1991)
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