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As metabolic psychiatry moves forward, we need both preclinical and larger, well-controlled clinical studies examining the pleiomorphic effects of ketone bodies in the brain and in the body to understand how we can best leverage whole foods to optimize brain energy, enhance genetic expression, reduce neuroinflammation, optimize metabolic health, and safeguard the promise of our future

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In another study, some subjects receiving 0.45–3.6 g/day curcumin for 1–4 months recorded nausea and diarrhea and elevated serum alkaline phosphatase and lactate dehydrogenase contents (294)