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Treatment with SOD has experimentally been shown to reduce liver oxidative stress in diabetic animals.[79] SOD mimetic (Mn[II][pyane] Cl2) has successfully been used to treat diabetes in diabetic rats.[80] Chemically modified SOD (carboxymethylcellulose-SOD and poly methyl vinyl ether-co-maleic anhydride-SOD) was effective in treating diabetes and offers a therapeutic advantage in clinical use.[81] It has been demonstrated that extracellular SOD can act as a therapeutic agent to protect the progression of diabetic nephropathy.[82] Current limitations of SODs for therapeutic applications Due to the instability, high immunogenicity, low cellular uptake, and lesser circulation in vivo half-life of SOD, their clinical applications as therapeutic agents are very limited

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doi: 10.1056/NEJMra1614676