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For instance, the bacterial metabolite Pseudomonas quinolone signal (PQS) activates host histidine methyltransferase carnosine-N-methyltransferase (CNMT), leading to epigenetic upregulation of transferrin receptor 1 (TFR1) and enhanced iron uptake, thereby promoting ferroptosis (Jia et al., 2025)

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37–40 Exposure of women to two or more early childhood stressful events, including physical, emotional, or sexual abuse, is positively correlated with an increased risk of Th1, Th2, and rheumatic autoimmune development later in life compared with women reporting no events in childhood (p 900 mcg/m 3 when indoor cooking stoves are used)