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IGF-1 DES is comprised of 67 amino acids and is distinguished by the absence of a tripeptide (consisting of 3 amino acids) at the N-terminus, unlike IGF-1, which contains 70 amino acids in its sequence

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In the CNS, GLP-1Rs are expressed by neurons in the hippocampus, which is known to be a cognition-related brain region, and have been observed in neocortical pyramidal neurons (Hamilton and Holscher, 2009)