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In a recent review (2018) by the famous Cochrane Institute, it was reported that studies which had been published on this topic only provided very low-quality evidence that oral B12 is as efficacious as intramuscular B12

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In aged tissue models (skin, liver, CNS), GHK-Cu Nrf2 activation reduces markers of oxidative senescence by approximately 38–44% relative to vehicle-aged controls, with ML385 (Nrf2 inhibitor) blocking approximately 68–74% of these effects