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These time-tested approaches, validated through centuries of observational practice, effectively pre-screen metal candidates and combinatorial protocols, thereby accelerating contemporary drug discovery pipelines ( As we reflect on the historical and contemporary roles of metals in medicine, it becomes evident that they are neither mere outcasts nor universally embraced ( 2 The early origins and modern evolution of mineral medicines in TCMM 2.1 The origins of mineral medicines in TCMM TCMM has been an integral part of Chinese medical practices for over 2,000 years and, importantly, it has been well documented