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Compared with the control group, study participants who supplemented with taurine had a significant improvement in the primary outcome of reducing risk of metabolic syndrome, demonstrated by the following weighted mean changes: systolic blood pressure - 4 mm Hg diastolic blood pressure -1.5 mm Hg triglycerides -18.3 mg/dL fasting blood glucose -5.9 mg/dL There were also significant improvements in secondary outcomes as shown by the following weighted mean changes: LDL cholesterol - 6.5 mg/dL total cholesterol - 8.3 mg/dL fasting insulin -1.52 µIU/L HOMA-IR (calculation of insulin resistance) - 0.7 There was no significant effect on HDL, body weight, and BMI

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Furthermore, the combination of cixutumumab with mitoxantrone-prednisone resulted in moderate disease control in another phase II trial (Table 2) [100]