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*Journal of medicinal chemistry*, *60*(12), 5015-5028

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fermentum CECT5716 reduced aortic TNF-α and VCAM-1 expression by 35% in HFD-fed rats ( 5.2 Clinical trials Clinical evidence, though limited by small sample sizes, supports probiotic benefits, Detailed characteristics of clinical trials investigating probiotics in atherosclerosis and related cardiovascular risk are summarized in Table 2 : Table 2 Clinical trials investigating probiotics and atherosclerosis/related cardiovascular risk