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First, we used IAV as an RNA virus model, in which viral RNA is known to be primarily sensed by RIG-I, leading to a potent IFN response essential for host survival 45,55,56

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In retina and optic nerve, TNFα is rapidly release from glial cells (i.e., microglia, Müller cells) as a response to cell-stress inducing factors, like increased intraocular pressure (Cueva Vargas et al., 2015)