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Thanks to the inhibition of de novo fatty acid synthesis and the alteration of the PPP and subsequent nucleotides and DNA synthesis, Metformin reduces the risk of PDAC in diabetic patients and has antitumor effects [52]

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These residues lead to the ubiquitin-dependent degradation of IkKα in the proteasome, resulting in the rapid and transient translocation of canonical NF-κB members from the cytoplasm to the nucleus