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In order to take POS research to the next level we should (i) further understand the molecular mechanisms controlling the hormetic POS phenomena, for example providing evidence for the role of kinases/phosphatases in the improvement of the antioxidant response in hypoxic tolerant species, and (ii) keep searching for the POS-response in nature (Moreira et al., 2017) having in mind the heterogeneity/diversity of POS phenotype among distinct tissues and animal species
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