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Payne (Eds.), Council for Agricultural Science and Technology Task Force Report2003;139Ames, Iowa, USA.1-88738-322-0 14

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Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) A substudy of the phase 2 obesity trial specifically examined GLP3’s effects on liver fat in participants with metabolic dysfunction-associated steatotic liver disease[12]: Mean relative liver fat reduction of 82.4% with 12 mg dose at 24 weeks 86% of participants on 12 mg achieved normal liver fat levels (below 5%) at 24 weeks Liver fat reductions significantly correlated with improvements in insulin sensitivity, abdominal fat, and metabolic parameters Dose-dependent improvements observed across all dose groups compared to placebo These results suggest potential therapeutic applications beyond weight management, addressing hepatic complications of obesity and metabolic syndrome